TRIFUNCTIONAL ANTIBODY-CYTOKINE FUSION PROTEIN FORMATS FOR TUMOR-TARGETED COMBINATION OF IL-15 WITH IL-7 OR IL-21

Trifunctional antibody-cytokine fusion protein formats for tumor-targeted combination of IL-15 with IL-7 or IL-21

Cytokines from the common gamma chain receptor family, such as IL-15, IL-21 and IL-7, show promise for cancer immunotherapy and have been incorporated individually into the immunocytokine approach.However, their efficacy as monotherapy is limited.Here, we investigated the molecular design of tumor-directed trifunctional antibody-cytokine fusion pro

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Impact of a modified progressive Copenhagen adduction exercise programme on hip adduction strength and postexercise muscle soreness in professional footballers

Background Reduced hip adduction strength has been identified as a key predisposing factor in developing hip and groin injuries.The Copenhagen adduction programme has been shown to increase hip adduction strength in semiprofessional footballers but can cause muscle soreness.Therefore, a modified progressive Copenhagen adduction (MPCA) programme has

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